Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193757
Type: Artigo de periódico
Title: Mouse Liver Microsomes (mlm) Protect Erythrocytes Against Trifluoperazine (tfp) Induced And Mechanical Hemolysis Which Are Due To Tfp Microsomal Transformation And To The Action Of An Unidentified Water-soluble Microsomal Factor (uf).
Author: Meirelles, N C
Malheiros, S V
Ruggiero, A C
Degterev, I A
Abstract: Trifluoperazine (TFP), a phenothiazine derivative, produces either hemolysis or protection of erythrocytes under isosmotic conditions in a dose-dependent manner. The hemolytic effect of TFP is abolished in the presence of mouse liver microsomes (MLM) which is due, in part, to drug incorporation, transformation and a MLM enzyme driven metabolism. An unidentified water-soluble factor (or factors) derived from MLM has been found to protect erythrocytes against both mechanical and TFP-induced isosmotic hemolysis.
Subject: Animals
Biotransformation
Cells, Cultured
Erythrocytes
Hemolysis
Kinetics
Male
Mice
Microsomes, Liver
Nadp
Osmolar Concentration
Solubility
Trifluoperazine
Water
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/7737237
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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