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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePolymorphonuclear Phagocytosis And Killing In Workers Exposed To Inorganic Mercury.pt_BR
dc.contributor.authorPerlingeiro, R Cpt_BR
dc.contributor.authorQueiroz, M Lpt_BR
unicamp.authorR C Perlingeiro, Department of Pharmacology and Hemocentre, State University of Campinas, Faculty of Medical Sciences, UNICAMP, SP, Brazil.pt_BR
unicamp.author.externalM L Queiroz,pt
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectCandidapt_BR
dc.subjectHumanspt_BR
dc.subjectMalept_BR
dc.subjectMercurypt_BR
dc.subjectMiddle Agedpt_BR
dc.subjectNeutrophilspt_BR
dc.subjectOccupational Exposurept_BR
dc.subjectPeroxidasept_BR
dc.subjectPhagocytosispt_BR
dc.description.abstractThe ability of neutrophils to phagocytose and kill Candida species as well as the splenic phagocytic function were investigated in workers from a mercury-producing plant. In the neutrophil phagocytosis study, two species of Candida were used since in individuals with myeloperoxidase deficiency neutrophils are unable to kill Candida albicans, while Candida pseudotropicalis can be effectively lysed. Phagocytosis of both antigens and splenic phagocytic function were normal in all the workers studied. However, following ingestion of the organisms there was considerable reduction in the ability of neutrophils from exposed workers to kill both species of Candida, and this was not explained by a mild impairment of phagocytosis. After improvement in the hygiene conditions in the factory, a new evaluation was performed, 6 months later, in the same workers and urinary mercury concentrations were determined monthly in each worker. Despite a significant reduction in urinary mercury concentrations, a greater impairment in the ability of neutrophils to kill C. albicans was observed. The killing of C. pseudotropicalis presented no further impairment when compared to the previous evaluation. These results suggest that impairment of the lytic activity of neutrophils from workers with urinary mercury concentrations within the safe level for exposed population is due, at least in part, to some interference with myeloperoxidase activity. In addition, the mercury-NADPH complex, once formed, could limit the utilization of reduced pyridine nucleotides by NADPH-dependent enzymes such as NADPH oxidase, thereby inhibiting the PMN respiratory burst.en
dc.relation.ispartofInternational Journal Of Immunopharmacologypt_BR
dc.relation.ispartofabbreviationInt. J. Immunopharmacol.pt_BR
dc.date.issued1994-Decpt_BR
dc.identifier.citationInternational Journal Of Immunopharmacology. v. 16, n. 12, p. 1011-7, 1994-Dec.pt_BR
dc.language.isoengpt_BR
dc.description.volume16pt_BR
dc.description.firstpage1011-7pt_BR
dc.rightsfechadopt_BR
dc.rights.holderpt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0192-0561pt_BR
dc.identifier.doipt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/7705962pt_BR
dc.date.available2015-11-27T12:18:26Z-
dc.date.accessioned2015-11-27T12:18:26Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:18:26Z (GMT). No. of bitstreams: 0 Previous issue date: 1994en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193755-
dc.identifier.idPubmed7705962pt_BR
Appears in Collections:Unicamp - Artigos e Outros Documentos

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