Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193711
Type: Artigo de periódico
Title: Increased Insulin Circulating Levels Induced By Canatoxin In Rats.
Author: Ribeiro-DaSilva, G
Prado, J F
Abstract: Canatoxin, a proteic neurotoxin from Canavalia ensiformis seeds, raises circulating insulin levels and induces hypoglycemia in rats. The hyperinsulinemia produced by canatoxin (6 micrograms kg-1, 20 min; 108% of increase in female rats) was both time and dose dependent and lasted only about 30 min, while the fall in blood glucose levels (around 30%) was long lasting. The hyperinsulinemic response to canatoxin was greater in females (+108 +/- 18%) than males (+43 +/- 8%), but no difference was noted in the hypoglycemia. Pretreatment of rats with either naloxone, naltrexone, atropine or hexamethonium abolished both the hyperinsulinemia and the hypoglycemia. These data suggest that these phenomena are influenced by opioids and depend on parasympathetic stimulation.
Subject: Animals
Blood Glucose
Endorphins
Female
Hypoglycemia
Insulin
Lectins
Male
Narcotic Antagonists
Neurotoxins
Parasympathetic Nervous System
Parasympathomimetics
Plant Proteins
Radioimmunoassay
Rats
Rats, Wistar
Sex Characteristics
Stimulation, Chemical
Toxins, Biological
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/8266345
Date Issue: 1993
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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