Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193671
Type: Artigo de periódico
Title: Opioid Nature Of Learned Helplessness And Stress Induced Analgesia Observed Without Re-exposure To Shock.
Author: Hunziker, M.H.L.
Abstract: It has been shown that uncontrollable shocks that produce learned helplessness also produce long-term opioid analgesia if th animal is re-exposed to shock immediately before the test. The present study was conducted in order to investigate if this effect can be observed 24h after the uncontrollable shock treatment without re-exposure to shock, and if it is opioid mediated. Long-term analgesia was found in the absence of re-exposure to shock, and was prevented by an i.p. injection of naloxone (10mg/kg) administered 10min before the test. The learned helplessness effect produced by the same shock treatment was prevented by the administration of 10 and 20mg/kg of naloxone 10min before the shuttlebox test, but not by a lower naloxone dose (5mg/kg). These findings suggest that the shock re-exposure requirement proposed in previous studies is not crucial in determining the long-term analgesia, and that both the long-term analgesia and the learned helplessness effect produced by this shock treatment were opioid mediated.
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/11224108
Date Issue: 1992
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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