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Type: Artigo de periódico
Title: Inotropic Effect Of Hyperosmotic Nacl Solutions On The Isolated Rat Cardiac Tissue.
Author: Bassani, J W
Bassani, R A
Rocha-e-Silva, M
Abstract: The inotropic effect of Krebs-Henseleit solution rendered hyperosmotic by addition of NaCl or sucrose (increments of 50, 100, 150 and 200 mOsm/l) on myocardial contractile activity was studied in rat isolated left atria paced at 4, 16 and 64 stim/min. The solutions did not affect the peak tension (Tp) at 4 stim/min, whereas sucrose caused a dose-dependent increase in Tp at 16 stim/min and NaCl decreased Tp at 64 stim/min. The total time duration of the contraction was increased in a dose-dependent fashion by both solutes, but the effect of NaCl was attenuated at 64 stim/min. The results showed that, in the isolated rat atrial tissue exposed to hyperosmotic NaCl solutions, the negative inotropic effect of increased Na+ concentration overcomes the positive influence of hyperosmolality only at higher pacing rates (about 1 Hz).
Subject: Animals
Atrial Function
Depression, Chemical
Myocardial Contraction
Osmolar Concentration
Rats, Inbred Strains
Saline Solution, Hypertonic
Stimulation, Chemical
Rights: fechado
Identifier DOI: 
Date Issue: 1990
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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