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|Type:||Artigo de periódico|
|Title:||Inotropic Effect Of Hyperosmotic Nacl Solutions On The Isolated Rat Cardiac Tissue.|
|Author:||Bassani, J W|
Bassani, R A
|Abstract:||The inotropic effect of Krebs-Henseleit solution rendered hyperosmotic by addition of NaCl or sucrose (increments of 50, 100, 150 and 200 mOsm/l) on myocardial contractile activity was studied in rat isolated left atria paced at 4, 16 and 64 stim/min. The solutions did not affect the peak tension (Tp) at 4 stim/min, whereas sucrose caused a dose-dependent increase in Tp at 16 stim/min and NaCl decreased Tp at 64 stim/min. The total time duration of the contraction was increased in a dose-dependent fashion by both solutes, but the effect of NaCl was attenuated at 64 stim/min. The results showed that, in the isolated rat atrial tissue exposed to hyperosmotic NaCl solutions, the negative inotropic effect of increased Na+ concentration overcomes the positive influence of hyperosmolality only at higher pacing rates (about 1 Hz).|
Rats, Inbred Strains
Saline Solution, Hypertonic
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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