Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193624
Type: Artigo de periódico
Title: Sex-related Canatoxin-induced Blood Glucose Alterations In The Rat.
Author: Pires-Barbosa, R
Ribeiro-DaSilva, G
Abstract: 1. The present study was designed to characterize sex-related canatoxin-induced blood glucose alterations in rats. 2. Chronic administration of canatoxin (50 mU, ip, daily for 3 days) induced hypoglycemia in female rats (N = 6) (-36.54 +/- 3.24%, P less than 0.05). The response of pregnant rats (N = 8) was similar to that observed for male rats (+29.57 +/- 4.70%). 3. Administration of canatoxin did not modify blood glucose levels of gonadectomized male or female rats. Similarly, pretreatment of intact male or female rats with human chorionic gonadotropin (40 IU/kg, im) blocked the effect of canatoxin on blood glucose levels. 4. Gonadal steroid replacement (testosterone, 10 mg/kg, im) for gonadectomized male rats did not reverse the inhibition of canatoxin-induced blood glucose alterations, whereas pretreatment of intact female rats (N = 6) with testosterone (10 mg/kg, im) significantly attenuated the canatoxin-induced hypoglycemia. 5. These data indicate that the blood glucose alterations produced by canatoxin in rats are under hormonal regulation.
Subject: Animals
Blood Glucose
Castration
Female
Lectins
Lethal Dose 50
Male
Plant Proteins
Pregnancy
Rats
Rats, Inbred Strains
Sex Characteristics
Toxins, Biological
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/2641357
Date Issue: 1989
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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