Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193623
Type: Artigo de periódico
Title: Effect Of Metronidazole On Platelet Aggregation.
Author: Prado-Franceschi, J
Antunes, E
Abstract: The effects of metronidazole on platelet aggregation induced by several agonists were studied on guinea pig and human platelet-rich plasma. Metronidazole (0.25-2.5 mg/ml) showed a dose-dependent inhibitory effect on in vitro aggregation of platelets from either source induced by adenosine-5-diphosphate (ADP), platelet aggregating factor (PAF), epinephrine, collagen or convulxin (extracted from Crotalus durissus terrificus venom). Total or partial inhibition was also detected in metronidazole pre-treated guinea pig platelet-rich plasma when challenged with PAF or ADP 45 and 135 min after oral treatment, respectively. This inhibition was both dose and time dependent.
Subject: Adenosine Diphosphate
Animals
Crotalid Venoms
Epinephrine
Guinea Pigs
Humans
Lectins, C-type
Metronidazole
Platelet Activating Factor
Platelet Aggregation Inhibitors
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/2641356
Date Issue: 1989
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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