Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193621
Type: Artigo de periódico
Title: [neuropathy Caused By Amiodarone: Clinico-pathologic Study Of 2 Cases].
Author: Maciel Júnior, J A
Queiroz, L
Abstract: Two patients, a 40-year-old woman and a 75-year-old man, were investigated due to a chronic polyneuritis. Amiodarone was used by them to treat refractory cardiac arrhythmia since 4 and 6 years before, respectively. The EMG study showed an axonal neuropathy. The light and electron-microscopical study of sural nerve displayed a loss of large myelinated fibers and a marked reduction of unmyelinated axons, associated with osmiophilic lamellated inclusions in Schwann cells and endothelial venulae. The interruption of amiodarone therapy improved neuropathy. Considered together with similar reports in perhexiline neuropathy and with chloroquine induced neuropathy this would stress the importance of these new drug-induced neurolipidosis.
Subject: Adult
Aged
Amiodarone
Arrhythmias, Cardiac
Axons
Biopsy
Female
Humans
Lipid Metabolism
Male
Polyneuropathies
Spinal Nerves
Sural Nerve
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/2634390
Date Issue: 1989
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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