Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193612
Type: Artigo
Title: Decreased C-peptide secretion in sickle cell anemia
Author: Saad, M. J.
Saad, S. T.
Braga, G.S.
Abstract: Intravenous glucose tolerance tests (IVGTT) were performed on 9 adults with sickle cell anemia and 15 normal controls. Blood samples were collected before and 1, 3, 5, 10, 20, 30, 40, 50, and 60 min after intravenous glucose infusion and used for glucose and C-peptide assays. The mean C-peptide concentration after glucose infusion was significantly (p less than 0.05) lower for the SCA patients as compared to the controls. No significant differences were observed in the glucose concentration of IVGTT between the two groups. These results suggest an inadequate insulin secretion by the endocrine pancreas in sickle cell anemia or an independent genetic abnormality in linkage disequilibrium with the beta s gene.
Intravenous glucose tolerance tests (IVGTT) were performed on 9 adults with sickle cell anemia and 15 normal controls. Blood samples were collected before and 1, 3, 5, 10, 20, 30, 40, 50, and 60 min after intravenous glucose infusion and used for glucose and C-peptide assays. The mean C-peptide concentration after glucose infusion was significantly (p less than 0.05) lower for the SCA patients as compared to the controls. No significant differences were observed in the glucose concentration of IVGTT between the two groups. These results suggest an inadequate insulin secretion by the endocrine pancreas in sickle cell anemia or an independent genetic abnormality in linkage disequilibrium with the beta s gene
Subject: Pâncreas
Insulina
Country: Suiça
Editor: Karger
Citation: Acta Haematologica. v. 82, n. 2, p. 81-4, 1989.
Rights: Fechado
Identifier DOI: 10.1159/000205288
Address: https://www.karger.com/Article/Abstract/205288
Date Issue: 1989
Appears in Collections:FCM - Artigos e Outros Documentos

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