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Type: Artigo de periódico
Title: Involvement Of Lipoxygenase And Cyclo-oxygenase Pathways In Hypoxia And Metabolic Alkalosis Produced By Canatoxin In Rats.
Author: Collares, C B
Ribeiro-da-Silva, G
Abstract: This paper reports on the metabolic alkalosis produced in rats by canatoxin, a neurotoxic principle extracted from Canavalia ensiformis seeds. Rats receiving canatoxin showed increased blood bicarbonate concentration with alkaline pH and no change in pCO2. A fall in pO2 was also seen. A dose-dependent relationship between pO2 decrease and bicarbonate increase was also observed with the toxin, suggesting that hypoxia may result from respiratory compensation. Canatoxin-induced hypoxia was both lipoxygenase and cyclo-oxygenase dependent but metabolic alkalosis was only blocked with cyclo-oxygenase inhibitors. Canatoxin activates the lipoxygenase pathway and probably increases leukotriene (LT) production. Since LT may release cyclo-oxygenase products, this may explain the metabolic alkalosis observed with canatoxin.
Subject: Acid-base Equilibrium
Hydrogen-ion Concentration
Plant Proteins
Prostaglandin-endoperoxide Synthases
Rats, Inbred Strains
Toxins, Biological
Rights: aberto
Identifier DOI: 
Date Issue: 1988
Appears in Collections:Unicamp - Artigos e Outros Documentos

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