Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193590
Type: Artigo de periódico
Title: Ca2+-dependent Nad(p)+-induced Alterations Of Rat Liver And Hepatoma Mitochondrial Membrane Permeability.
Author: Vercesi, A E
Ferraz, V L
Macedo, D V
Fiskum, G
Abstract: Deenergized rat liver or AS-30D hepatoma mitochondria underwent extensive swelling when incubated in the presence of Ca2+ and an oxidant of mitochondrial pyridine nucleotides. This swelling was stimulated by phosphate and inhibited by ruthenium red, Mg2+ plus ATP and dibucaine. The degree of inhibition by dibucaine was shown to vary inversely with the Ca2+ concentration. The inhibition caused by ruthenium red was completely removed by the Ca2+ ionophore ionomycin indicating that the effect of the cation is mediated by internal binding sites. Since mitochondria were totally deenergized the data definitely rule out the requirement for Ca2+ cycling across the membrane in this mechanism.
Subject: Animals
Calcium Chloride
Diamide
Dibucaine
Egtazic Acid
Ethers
Intracellular Membranes
Ionomycin
Kinetics
Liver Neoplasms, Experimental
Male
Mitochondria
Mitochondria, Liver
Mitochondrial Swelling
Nad
Nadp
Permeability
Rats
Rats, Inbred Strains
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/3136771
Date Issue: 1988
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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