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Type: Artigo de periódico
Title: Chronotropic And Inotropic Effects Of Hyperosmotic Solutions On Right And Left Atria Isolated From The Rat Heart.
Author: Bassani, J W
Bassani, R A
Rocha-e-Silva, M
Abstract: The chronotropic and inotropic effects of hyperosmotic solutions (HS) on isolated rat atria were studied to determine the influences of solute, time and blockade of autonomic receptors. NaCl and sucrose HS (450 mOsm/1) exerted a time-dependent negative chronotropic effect on right atria. NaCl decreased whereas sucrose increased peak tension of the left atria. Phenoxybenzamine and propranolol did not change the chronotropic effects of hyperosmolality, but increased the peak tension of left atria exposed to HS. We conclude that chronotropic effects of HS seem to be non-specific while inotropic effects depend on the solute and may involve neurotransmitter release, probably acetylcholine.
Subject: Acetylcholine
Analysis Of Variance
Glucose Solution, Hypertonic
Heart Atria
Heart Rate
Myocardial Contraction
Neuromuscular Blocking Agents
Rats, Inbred Strains
Receptors, Adrenergic
Saline Solution, Hypertonic
Sodium Chloride
Rights: aberto
Identifier DOI: 
Date Issue: 1987
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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