Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193575
Type: Artigo de periódico
Title: Effects Of Footshock Stress On The Sensitivity Of The Isolated Rat Pacemaker To Catecholamines.
Author: Bassani, R A
De Moraes, S
Abstract: The effect of repeated footshock on the sensitivity of the isolated rat pacemaker to the chronotropic effect of catecholamines was studied. Footshock stress caused subsensitivity to noradrenaline and supersensitivity to isoprenaline. The subsensitivity to the neurotransmitter was abolished by cocaine, whereas supersensitivity to isoprenaline was unchanged after blockade of the extraneuronal uptake. The pA2 value of metoprolol was increased by repeated footshock. Butoxamine reversed the supersensitivity to isoprenaline and the alteration of the pA2 value. Repeated footshock stress appears to cause prejunctional subsensitivity to noradrenaline and to increase the function of postjunctional beta 2-adrenoceptors.
Subject: Adrenergic Beta-antagonists
Animals
Cocaine
Electroshock
Heart Rate
Isoproterenol
Male
Norepinephrine
Phenoxybenzamine
Rats
Rats, Inbred Strains
Stress, Physiological
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/2897865
Date Issue: 1987
Appears in Collections:Unicamp - Artigos e Outros Documentos

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