Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/1862
Type: Artigo de periódico
Title: Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams
Author: Spadotto, Raquel
Damasceno, Debora Cristina
Godinho, Antonio Francisco
Porto Amorim, Elaine Manoela
Perobelli, Juliana Elaine
Kempinas, Wilma De Grava
Abstract: Objectives: The objective of this study was to evaluate physical and sexual development and reproductive physiology in female rat offspring that developed in hyperglycemia conditions in utero and during lactation. Materials and methods: Maternal diabetes was induced in female rats by a single IV injection of streptozotocin before mating. Female offspring development was evaluated by means of the following parameters: physical development; age of vaginal opening and first estrus; weight and histological evaluation of uterus and ovaries.; duration of the estrous cycle, sexual behavior, and fertility after natural mating. Results: In the female offspring, maternal diabetes caused delays in initial physical development; diminution in ovary weight and number of follicles; and inferior reproductive performance compared with the control group. Conclusions: The exposure to hyperglycemia in uterus and during lactation caused delays in physical and sexual development, and affected the reproductive physiology of female rats negatively. Arq Bras Endocrinol Metab. 2012;56(2):96-103
Subject: Sexual behavior
physical development
diabetes
female reproductive physiology
female rat
streptozotocin
Country: Brazil
Editor: Sbem-Soc Brasil Endocrinologia & Metabologia
Rights: fechado
Date Issue: 2012
Appears in Collections:IB - Artigos e Outros Documentos

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