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Type: Artigo de periódico
Title: The functional role of ascending nociceptive control in defensive behavior
Author: Tambeli, Claudia Herrera
Fischer, Luana
Monaliza, Simone Lamana
Menescal-de-Oliueira, Leda
Parada, Carlos Amilcar
Abstract: Ascending nociceptive control is a novel spino-striato-rostral ventral medulla pain modulation pathway that mediates heterosegmental pain-induced analgesia, i.e., noxious stimulus-induced antinociception. In this study, we used the dorsal immobility response in rats as a model of the defensive responses. We demonstrated that the activation of ascending nociceptive control by peripheral noxious stimulation and spinal AMPA and mGluR1 receptor blockade significantly potentiated the duration of the dorsal immobility response in rats via an opioid-dependent mechanism in the nucleus accumbens. These results demonstrated the functional role of ascending nociceptive control in the modulation of defensive responses and spinal glutamatergic receptors in the dorsal immobility response. The immobility response is an antipredator behavior that reflects the underlying state of fear, and ascending nociceptive control may modulate fear. (c) 2012 Elsevier B.V. All rights reserved.
Subject: Nucleus accumbens
Noxious stimulation
Ascending nociceptive control
Dorsal immobility response
Defensive response
Spinal glutamatergic receptor
Editor: Elsevier
Rights: fechado
Identifier DOI: 10.1016/j.brainres.2012.05.010
Date Issue: 2012
Appears in Collections:IB - Artigos e Outros Documentos

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