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Type: Artigo de periódico
Title: eNOS Tag SNP Haplotypes in Hypertensive Disorders of Pregnancy
Author: Muniz, Ludmila
Luizon, Marcelo R.
Palei, Ana C. T.
Lacchini, Riccardo
Duarte, Geraldo
Cavalli, Ricardo C.
Tanus-Santos, Jose E.
Sandrim, Valeria C.
Abstract: Haplotypes formed by polymorphisms (T-786C, rs2070744; a variable number of tandem repeats in intron 4, and Glu298Asp, rs1799983) of the eNOS gene were associated previously with gestational hypertension (GH) and preeclampsia (PE). However, no study has explored the Tag SNPs rs743506 and rs7830 in these disorders. The aim of the current study was to compare the distribution of the genotypes and haplotypes formed by the five eNOS polymorphisms mentioned among healthy pregnant (HP, n = 122), GH (n = 138), and PE (n = 157). The haplotype formed by "C b G G C" was more frequent in HP compared to GH and PE (p = 0.0071), which is supported by previous findings that demonstrated the association of the combination "C b G" with a higher level of nitrite (NO marker). Our results suggest a protective effect of the haplotype "C b G G C" against the development of hypertensive disorders of pregnancy.
Editor: Mary Ann Liebert Inc
Rights: fechado
Identifier DOI: 10.1089/dna.2012.1768
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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