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Type: Artigo de periódico
Title: Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine
Author: Martins-Oliveira, Alisson
Goncalves, Flavia M.
Speciali, Jose G.
Fontana, Vanessa
Izidoro-Toledo, Tatiane C.
Belo, Vanessa A.
Dach, Fabiola
Tanus-Santos, Jose E.
Abstract: We investigated whether three relevant polymorphisms (C-1562T, microsatellite - 90(CA)(14-24), and Q279R) in the MMP-9 gene, or MMP-9 haplotypes, are associated with migraine and affect MMP-9 and tissue inhibitor of MMPs (TIMP)-1 levels in patients with migraine. We studied 102 healthy women (controls) and 187 women with migraine (141 without aura - MWA, and 46 with aura - MA). Patients with MWA had higher plasma MMP-9 concentrations than patients with MA. Patients with MA had the highest TIMP-1 and lowest MMP-9/TIMP-1 ratios. The MMP-9 "C L Q" haplotype was associated with higher plasma MMP-9 concentrations in migraine patients. (C) 2012 Elsevier B.V. All rights reserved.
Subject: Haplotype
Matrix metalloproteinase-9
Editor: Elsevier
Citation: Journal of Neuroimmunology. Elsevier, v.252, n.41306, p.89-94, 2012
Rights: fechado
Identifier DOI: 10.1016/j.jneuroim.2012.07.016
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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