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Type: Artigo de periódico
Title: Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients
Author: Lacchini, R.
Jacob-Ferreira, A. L. B.
Luizon, M. R.
Gasparini, S.
Ferreira-Sae, M. C. S.
Schreiber, R.
Nadruz, W., Jr.
Tanus-Santos, J. E.
Abstract: Matrix metalloproteinases (MMPs) are involved in cardiac remodelling. We examined whether MMP-2 genetic polymorphisms are associated with hypertension and left ventricular (LV) remodelling in hypertensive patients. We studied 160 hypertensive patients and 123 healthy controls. Echocardiography was performed in all patients and the C-1306T (rs243865) and C-735T (rs 2285053) MMP-2 polymorphisms were analysed. Haplo.stats analysis was used to evaluate whether MMP-2 haplotypes are associated with hypertension and with extremes in LV mass index (LVMI). Multiple linear regression analysis was performed to assess whether MMP-2 genotypes or haplotypes affect LVMI and other echocardiography parameters. The C-1306T 'CC' genotype was associated with reduced LVMI and LV end-diastolic diameter (EDD) (P=0.0365 and P=0.0438, respectively). The haplotype 'C, C' was associated with reduced LVMI and EDD (P=0.0278 and P=0.0322, respectively). The comparison of upper and lower extremes of the LVMI phenotype showed that the 'C, C' haplotype was more common in the lower LVMI group (P=0.0060), whereas the 'T, C' haplotype was more common in the higher quartile of LVMI (P=0.0187), and this haplotype was associated with increased risk of higher LVMI values (odds ratio=3.5121, 95% confidence interval 1.3193-9.3494). The findings suggest that MMP-2 polymorphisms affect hypertension-induced LV remodelling. Journal of Human Hypertension (2012) 26, 171-177; doi:10.1038/jhh.2011.8; published online 10 February 2011
Subject: left ventricular hypertrophy
MMP-2 polymorphisms
Heart remodelling
MMP-2 haplotypes
Editor: Nature Publishing Group
Citation: Journal of Human Hypertension. Nature Publishing Group, v.26, n.3, p.171-177, 2012
Rights: fechado
Identifier DOI: 10.1038/jhh.2011.8
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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