Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/1784
Type: Artigo de periódico
Title: Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy
Author: Amaral, L. M.
Palei, A. C. T.
Sandrim, V. C.
Luizon, M. R.
Cavalli, R. C.
Duarte, G.
Tanus-Santos, J. E.
Abstract: Increased expression and activity of inducible nitric oxide synthase (iNOS) may contribute to the pathogenesis of pre-eclampsia (PE) and gestational hypertension (GH). However, no previous study has examined whether genetic polymorphisms in the iNOS gene are associated with PE or GH. We examined whether two functional, clinically relevant iNOS genetic polymorphisms (the C(-1026)A polymorphism, rs2779249, in the promoter region, and the G2087A polymorphism, rs2297518, in exon 16) are associated with GH or with PE. We studied 565 pregnant women: 212 healthy pregnant (HP), 166 pregnant with GH and 187 pregnant with PE. Genotypes were determined by real-time PCR, using the Taqman allele discrimination assay. The PHASE 2.1 program was used to estimate haplotype distributions in the three study groups. We found no significant association between the C(-1026)A polymorphism and PE or GH (P>0.05). However, we found the GA genotype and the A allele for the G2087A polymorphism at higher frequency in PE, but not in GH, compared with HP (P<0.05). The haplotype analysis showed no significant intergroup differences (P>0.05). These findings suggest that iNOS genetic variants may affect the susceptibility to PE, but not to GH. Journal of Human Hypertension (2012) 26, 547-552; doi:10.1038/jhh.2011.65; published online 30 June 2011
Subject: gestational hypertension
inducible nitric oxide synthase
polymorphism
pre-eclampsia
Editor: Nature Publishing Group
Rights: fechado
Identifier DOI: 10.1038/jhh.2011.65
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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