Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/1255
Type: Artigo de periódico
Title: A majority of Brazilian patients with rheumatoid arthritis HLA-DRB1 alleles carry both the HLA-DRB1 shared epitope and anti-citrunillated peptide antibodies
Author: LOUZADA-JÚNIOR, P.
FREITAS, M.V.C.
OLIVEIRA, R.D.R.
DEGHAIDE, N.H.S.
CONDE, R.A.
BERTOLO, M.B.
DONADI, E.A.
Abstract: The objective of the present study was to evaluate the contribution of the shared epitope (SE), the rheumatoid arthritis (RA) protection model, and the occurrence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in RA patients from a genetically diverse population. One hundred and forty Brazilian RA patients and 161 matched controls were typed for HLA-DRB1 alleles using amplified DNA hybridized with sequence-specific oligonucleotide probes or primers. Patients were stratified according to the presence or absence of SE (DRB1*0401, *0404, *0405, *0101, *1001, and *1402), of the DERAA alleles (DRB1*0103, *0402, *1102, *1103, *1301, *1302, and *1304), and X (all other alleles). Anti-CCP antibodies were measured by ELISA. The combined frequency of SE-positive alleles was significantly greater (76.4 vs 23.6%, P < 0.0001) than the controls. The SE/SE and SE/X genotypes were over-represented (P < 0.0001, OR = 6.02) and DERAA/X was under-represented in RA patients (P < 0.001, OR = 0.49), whereas the frequencies of the SE/DERAA, X/X and X/DERAA genotypes were not significantly different from controls. The frequency of anti-CCP antibodies was higher in SE-positive patients than in SE-negative patients (64.6 vs 44.7%, P = 0.03; OR = 2.25). Although the Brazilian population is highly miscegenated, the results of this study support the findings observed in most genetically homogeneous populations with RA; however, they are not mutually exclusive but rather complementary. The participation of DRB1-DERAA alleles in protection against RA was also observed (OR = 0.4; 95%CI = 0.23-0.68).
Subject: Susceptibility to rheumatoid arthritis
HLA
Brazilians
Shared epitope
Anti-cyclic citrullinated peptide
Country: Brasil
Editor: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research, v.41, n.6, p.493-499, 2008
Rights: aberto
Identifier DOI: 10.1590/S0100-879X2008005000021
Address: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600010
http://www.scielo.br/pdf/bjmbr/v41n6/7002.pdf
Date Issue: 2008
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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