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Type: Artigo de periódico
Title: Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae)
Title Alternative: Cytochalasins produced by Xylaria sp., an endophytic fungus from Piper aduncum
Author: SILVA, Geraldo H.
OLIVEIRA, Camila M. de
TELES, Helder L.
BOLZANI, Vanderlan da S.
ARAUJO, Angela R.
YOUNG, Maria Claudia M.
COSTA-NETO, Claudio M.
HADDAD, Renato
EBERLIN, Marcos N.
Abstract: A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae.
Subject: Xylaria sp.
Piper aduncum
Endophytic fungus
Country: Brasil
Editor: Sociedade Brasileira de Química
Citation: Química Nova, v.33, n.10, p.2038-2041, 2010
Rights: aberto
Identifier DOI: 10.1590/S0100-40422010001000006
Date Issue: 2010
Appears in Collections:IQ - Artigos e Materiais de Revistas Científicas

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