Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/1107
Type: Artigo de periódico
Title: Stimulation of Acidic Reduction of Nitrite to Nitric Oxide by Soybean Phenolics: Possible Relevance to Gastrointestinal Host Defense
Author: FERREIRA, Pablo Gomes
LIMA, Maria Angelica Suedan Souza
BERNEDO-NAVARRO, Robert Alvin
CONCEICAO, Rogerio Arcuri
LINHARES, Edlaine
SAWAYA, Alexandra Christine Helena Frankland
YANO, Tomomasa
SALGADO, Ione
Abstract: This study aimed to evaluate the potential of soybean-promoted acidic nitrite reduction and to correlate this activity with the content of phenolics and with the bactericidal activity against Escherichia coli O157:H7. Extracts of embrionary axes and cotyledons enriched in phenolics increased (center dot)NO formation at acidic pH at values that were 7.1 and 4.5 times higher, respectively, when compared to the reduction of the nonenriched extracts. Among the various phenolics accumulated in the soybean extracts, five stimulated nitrite reduction in the following decreasing order of potency: epicatechin gallate, chlorogenic acid, caffeic acid, galic acid and p-coumaric acid. Extracts of embrionary axes presented higher contents of epicatechin gallate and caffeic acid, compared to that of cotyledons, indicating a positive correlation between activity of the extracts and content of phenolics with regard to nitrite reducing activity. Soybean extracts enriched in phenolics interacted synergistically with acidified nitrite to prevent E. coli O157:H7 growth. The results suggest that soybean phenolics may interfere with the metabolism of (center dot)NO in an acidic environment by accelerating the reduction of nitrite, with a potential antimicrobial effect in the stomach.
Subject: nitric oxide
nitrous acid reduction
phenolics
soybean
bactericidal effect
Escherichia coli O157:H7
Country: Estados Unidos
Editor: AMER CHEMICAL SOC
Citation: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.59, n.10, p.5609-5616, 2011
Rights: fechado
Identifier DOI: 10.1021/jf201229x
Address: http://dx.doi.org/10.1021/jf201229x
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Date Issue: 2011
Appears in Collections:IB - Artigos e Materiais de Revistas Científicas

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