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Type: Artigo de periódico
Title: Differences and similarities of postprandial lipemia in rodents and humans
Author: PANZOLDO, Natalia B.
URBAN, Aline
PARRA, Eliane S.
ZAGO, Vanessa S.
SILVA, Livia R. da
FARIA, Eliana C. de
Abstract: Background: The rat has been a mainstay of physiological and metabolic research, and more recently mice. This study aimed at characterizing the postprandial triglyceride profile of two members of the Muridae family: the Wistar rats (Rattus norvegicus albinus) and C57BL/6 mice (Mus musculus) plus comparing them to the profile obtained in humans. Methods: Thirty-one male and twelve female Wistar rats, ten C57BL/6 male and nine female mice received a liquid meal containing fat (17%), protein (4%) and carbohydrates (4%), providing 2 g fat/Kg. Thirty-one men and twenty-nine women received a standardized liquid meal containing fat (25%), dextromaltose (55%), protein (14%), and vitamins and minerals (6%), and providing 40 g of fat per square meter of body surface. Serial blood samples were collected at 2, 4, 6, 8 and 10 h after the ingestion in rats, at 1, 2, 3, 4, 5 and 6 h in mice and in humans at 2, 4, 6 and 8 h. Wilcoxon and Mann-Whitney tests were used. Results/Discussion: The triglyceride responses were evaluated after the oral fat loads. Fasting and postprandial triglyceridemia were determined sequentially in blood sample. AUC, AUIC, AR, RR and late peaks were determined. Conclusions: Rats are prone to respond in a pro-atherogenic manner. The responses in mice were closer to the ones in healthy men. This study presents striking differences in postprandial triglycerides patterns between rats and mice not correlated to baseline triglycerides, the animal baseline body weight or fat load in all animal groups.
Subject: oral fat tolerance test
triglyceride-rich lipoproteins
remnant-like particle
Country: Inglaterra
Citation: LIPIDS IN HEALTH AND DISEASE, v.10, 2011
Rights: fechado
Identifier DOI: 10.1186/1476-511X-10-86
Date Issue: 2011
Appears in Collections:FCM - Artigos e Outros Documentos

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