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Type: Artigo de periódico
Title: Determination Of β S Plotypes In Patients With Sickle-cell Anemia In The State Of Rio Grande Do Norte, Brazil
Author: Cabral C.H.K.
Serafim EdvisS.S.
de Medeiros W.R.D.B.
Fernandes T.A.A.M.
Kimura E.M.
Costa F.F.
de Fatima Sonati M.
Rebecchi I.M.M.
de Medeiros T.M.D.
Abstract: β s haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte. © 2011, Sociedade Brasileira de Genética.
Rights: aberto
Identifier DOI: 10.1590/S1415-47572011005000027
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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