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Type: Artigo de periódico
Title: Effects Of Alcoholism And Alcoholic Detoxication On The Repair And Biomechanics Of Bone
Author: Horvath R.O.
Da Silva T.D.
Neto J.C.
Nakagaki W.R.
Garcia J.A.D.
Soares E.A.
Abstract: Objective: To evaluate the effects of chronic ethanol consumption and alcohol detoxication on the mechanical resistance of bone and bone neoformation around dense hydroxyapatite implants (DHA) in rats. Methods: Fifteen rats were separated into three groups: (1) control group (CT); (2) chronic alcoholic (CA), and (3) disintoxicated (DI). After four weeks, a DHA was implanted in the right tibia of the animals, and the CA group continued consuming ethanol, while the DI group started detoxication. The solid and liquid feeding of the animals was recorded, and a new alcohol dilution was effected every 48 hours. After 13 weeks, the animals were euthanized and their biological material was collected. Results: Bone tissue was found around DHA in all the animals. Group CA showed less bone neoformation, lower levels of ionic and total calcium when compared to the animals of the CT and DI groups. The DI animals showed higher values in all the variables in relation to the CA group. Conclusion: Ethanol consumption interfered in osteogenesis around the DHA implants, and in calcium levels and mechanical bone resistance. Alcohol detoxication was effective, as it increased osteogenesis, DHA osteointegration, calcemia, and mechanical resistance of the b one. Level of Evidence: Level I, therapeutic studies.
Rights: aberto
Identifier DOI: 
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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