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Type: Artigo de periódico
Title: Female Urethral Carcinoma: Evidences To Origin From Skene's Glands
Author: Reis L.O.
Billis A.
Ferreira F.T.
Ikari L.Y.
Stellini R.F.
Ferreira U.
Abstract: Purpose: Urethral carcinoma is among the rarest neoplasias of the genitourinary tract and its origin is unclear. Prostate-specific antigen (PSA) is considered an evidence of origin from Skene's glands. We considered the origin from these glands in PSA negative cases. Material and methods: We studied 3 patients with urethral carcinoma surgically treated. The surgical specimens were examined including cytochemical and immunohistochemical stains. The possible origin of the tumors was based on a comparative study of normal Skene's glands from autopsies and noninvolved glands in periurethral tumors. Results: The gross findings and the microscopic examination of 2 adenocarcinomas, including the cytochemical and immunohistochemical studies, favor an origin from Skene's glands. Conclusions: The origin from Skene's glands may be established in PSA negative cases. The establishment of this origin in a higher number of urethral carcinomas may have an impact on diagnostic and treatment strategies in the future. © 2011 Elsevier Inc.
Rights: fechado
Identifier DOI: 10.1016/j.urolonc.2009.03.019
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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