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|Type:||Artigo de periódico|
|Title:||Nmr Studies Of Inclusion Complexation Of The Pyrrolizidine Alkaloid Retronecine And P-sulfonic Acid Calixarene|
|Author:||Da Silva D.L.|
Do Couto Tavares E.
De Souza Conegero L.
De Fatima A.
|Abstract:||Accidental or intentional drug toxicity in humans and animals is a major concern and the search for detoxificant agents is a challenge. Pyrrolizidine-producing forages are a threat not only to livestock, but also to humans as a consequence of food contamination. Supramolecular systems are promising as detoxificant agents by decreasing the bioavailability of toxic compounds in biological environment. Cyclodextrin and calix[n]arenes are well known hosts for a variety of molecules and/or ions. Surprisingly, only few studies describe the potential of calix[n]arenes as host for toxic molecules. This study focused on the use of NMR techniques as tools for the investigation of the interactions between p-sulfonic acid calixarene and retronecine, a toxic pyrrolizidine alkaloid. © 2010 Springer Science+Business Media B.V.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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