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Type: Artigo de periódico
Title: Nmr Studies Of Inclusion Complexation Of The Pyrrolizidine Alkaloid Retronecine And P-sulfonic Acid Calix[6]arene
Author: Da Silva D.L.
Do Couto Tavares E.
De Souza Conegero L.
De Fatima A.
Pilli R.A.
Fernandes S.A.
Abstract: Accidental or intentional drug toxicity in humans and animals is a major concern and the search for detoxificant agents is a challenge. Pyrrolizidine-producing forages are a threat not only to livestock, but also to humans as a consequence of food contamination. Supramolecular systems are promising as detoxificant agents by decreasing the bioavailability of toxic compounds in biological environment. Cyclodextrin and calix[n]arenes are well known hosts for a variety of molecules and/or ions. Surprisingly, only few studies describe the potential of calix[n]arenes as host for toxic molecules. This study focused on the use of NMR techniques as tools for the investigation of the interactions between p-sulfonic acid calix[6]arene and retronecine, a toxic pyrrolizidine alkaloid. © 2010 Springer Science+Business Media B.V.
Rights: fechado
Identifier DOI: 10.1007/s10847-010-9825-1
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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