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Type: Artigo de periódico
Title: Chlorella Vulgaris Restores Bone Marrow Cellularity And Cytokine Production In Lead-exposed Mice
Author: Queiroz M.L.S.
da Rocha M.C.
Torello C.O.
de Souza Queiroz J.
Bincoletto C.
Morgano M.A.
Romano M.R.
Paredes-Gamero E.J.
Barbosa C.M.V.
Calgarotto A.K.
Abstract: Chlorella vulgaris (CV) was examined for its modulating effects on the reduction induced by lead (Pb) on the numbers of marrow hematopoietic stem cells (HSCs) (c-Kit +Lin -), granulocyte-macrophage progenitors (Gr1 +Mac1 +) and total bone marrow cellularity. In mice gavage-treated daily with 50mg/kg dose of CV for 10days, concomitant to a continuous offering of 1300ppm lead acetate in drinking water, the treatment with the algae recovered the significantly reduced numbers of these cell populations to control values. As CV may have a myelostimulating effect through the induction of cytokines, we evaluated its modulating effects on the production of IL-1α, TNF-α, IFN-γ, IL-10 and IL-6. Our results demonstrated that lead significantly impairs the production of IFN-γ, IL-1α and TNF-α and increases the production of IL-10 and IL-6 and that these effects are successfully modulated by the CV treatment. The activity of NK cells, reduced in Pb-exposed animals, was raised to levels higher than those of controls in the exposed group treated with CV. Treatment with the algae also stimulated the production of IFN-γ, IL-1α, TNF-α and NK cells activity in normal mice. In addition, zinc bone concentrations, reduced in lead-exposed mice, were partially, but significantly, reversed by the treatment with CV. © 2011 Elsevier Ltd.
Rights: fechado
Identifier DOI: 10.1016/j.fct.2011.06.056
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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