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Type: Artigo de periódico
Title: Chemical, Spectroscopic Characterization, Dft Studies And Initial Pharmacological Assays Of A Silver(i) Complex With N-acetyl-l-cysteine
Author: Abbehausen C.
Heinrich T.A.
Abrao E.P.
Costa-Neto C.M.
Lustri W.R.
Formiga A.L.B.
Corbi P.P.
Abstract: A new silver(I) complex with N-acetyl-l-cysteine (NAC) of composition AgC5H8NO3S·H2O was synthesized and characterized by a set of chemical and spectroscopic measurements. Solid-state 13C nuclear magnetic resonance (SSNMR) and infrared (IR) analyses indicate the coordination of the ligand to Ag(I) through the sulfur atom. The Ag-NAC complex is slightly soluble in dimethyl sulfoxide. It is insoluble in water, methanol, ethanol, acetone and hexane. Antibacterial activity of the silver complex with N-acetyl-l-cysteine (Ag-NAC) was evaluated by antibiogram assays using the disc diffusion method. The compound showed an effective antibacterial activity against Staphylococcus aureus (Gram-positive), Escherichia coli and Pseudomonas aeruginosa (Gram-negative) bacterial cells. Biological analysis for evaluation of a potential cytotoxic effect of Ag-NAC was performed using HeLa cells derived from human cervical adenocarcinoma. The complex presented a significant cytotoxic activity, inducing 80% of cell death at a concentration of 200 μmol L-1. © 2010 Elsevier Ltd. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.poly.2010.11.025
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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