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Type: Artigo de periódico
Title: A Case Report Of Severe Congenital Neutropenia In A Young Infant [relato De Um Caso De Neutropenia Congênita Grave Em Um Lactente Jovem]
Author: dos Santos L.F.M.
Mukai A.O.
Bertoli C.J.
Fernandes T.A.R.
Suetugo C.P.
dos Santos L.F.M.
Abstract: Objective: To report a case of severe congenital neutropenia and alert pediatricians about its diagnosis in young patients with recurrent infectious diseases. Case description: Young infant with 45 days of life, with a history of high fever, lethargy, poor feeding and repeated blood counts showing significant leucopenia due to a significant decrease of polymorphonuclear cells. The diagnosis was confirmed by bone marrow aspirate showing hypoplasia of the granulocytic series and complete absence of mature neutrophils. Treatment was started with broad-spectrum antibiotic therapy and granulocyte colony-stimulating factor, but the patient died due to infectious complications 21 days after hospital admission.Comments: This is a young infant with a rare congenital disorder that leads to severe neutropenia and, therefore, susceptible to potentially fatal infections. In the hospital the infant showed signs and symptoms of sepsis. The diag nosis was based on the clinical history and the presence of repeated altered white cell counts and it was confirmed by bone marrow aspirate. Granulocyte colony-stimulating factor is generally effective, but, in this case, the patient died with a severe infection.
Rights: aberto
Identifier DOI: 10.1590/S0103-05822011000400032
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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