Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Anatomical Features Of The Urethra And Urinary Bladder Catheterization In Female Mice And Rats. An Essential Translational Tool [características Anatômicas Da Cateterização Da Uretra E Bexiga De Camundongos E Ratos Fêmeas. Instrumento Essencial Na Pesquisa Pré Clínica]
Author: Reis L.O.
Sopena J.M.G.
Favaro W.J.
Martin M.C.
Simao A.F.L.
dos Reis R.B.
de Andrade M.F.
Domenech J.D.
Cardo C.C.
Abstract: PURPOSE: To present fundamental anatomical aspects and technical skills necessary to urethra and urinary bladder catheterization in female mice and rats. METHODS: Urethral and bladder catheterization has been widely utilized for carcinogenesis and cancer research and still remains very useful in several applications: from toxicological purposes as well as inflammatory and infectious conditions to functional aspects as bladder dynamics and vesicoureteral reflux, among many others. RESULTS: Animal models are in the center of translational research and those involving rodents are the most important nowadays due to several advantages including human reproducibility, easy handling and low cost. CONCLUSIONS: Although technical and anatomical pearls for rodent urethral and bladder access are presented as tackles to the advancement of lower urinary tract preclinical investigation in a broaden sight, restriction to female animals hampers the male microenvironment, demanding future advances.
Rights: aberto
Identifier DOI: 10.1590/S0102-86502011000800019
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
2-s2.0-80555124917.pdf4.72 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.