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Type: Artigo de periódico
Title: Cytotoxic Derivatives Of Withanolides Isolated From The Leaves Of Acnistus Arborescens [derivados Citotóxicos De Vitanolidos Isolados Das Folhas De Acnistus Arborescens]
Author: Minguzzi S.
Barata L.E.S.
Cordell G.A.
Abstract: In view of anticancer activity of 7 β-acetoxywithanolide D (2) and 7β-16α-diacetoxywithonide D (3), isolated from the leaves of Acnistus arborescens (Solanaceae), five withanolide derivatives were obtained and their structures were determined by NMR, MS and IV data analysis. The in vitro anticancer activity of these derivatives was evaluated in a panel of cancer cell lines: human breast (BC-1), human lung (Lu1), human colon (Col2) and human oral epidermoid carcinoma (KB). Compounds 2a (acetylation of 2), 3b (oxidation of 3) and 2c (hydrogenation of 2) exhibited the highest anticancer activity against human lung cancer cells, with ED50 values of 0.19, 0.25 and 0.63 μg/mL, respectively.
Rights: aberto
Identifier DOI: 10.1590/S0100-40422011000200013
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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