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|Type:||Artigo de periódico|
|Title:||Metabolic Evaluation Of Young Women With Congenital Adrenal Hyperplasia [avaliação Metabólica Em Mulheres Jovens Com Hiperplasia Adrenal Congênita]|
de Lemos-Marini S.H.V.
de Mello M.P.
de Oliveira L.C.
|Abstract:||Objective: To evaluate insulin resistance and lipid profle in women with congenital adrenal hyperplasia (CAH) caused by classical 21-hydroxylase defciency (21OHD), and their association with body mass index (BMI) and corticosteroid dosage. Subjects and methods: We assessed BMI, waist circumference, current glucocorticoid dosage, glucose, insulin and lipid profle in eighteen young women (mean ± SD, 19.3 ± 3.0 years) with 21OHD CAH. Results: BMI was normal in 12 patients, 5 of them were overweight, and 1 was obese. Waist circumference was high in 7 patients. Fasting insulin and HOMA-IR were elevated in seven and eight patients, respectively. Total cholesterol and triglycerides were high in only two patients, and HDL-cholesterol was low in four. Insulin resistance was not associated with BMI, waist circumference or gluco-corticoid dose. Conclusions: Young women with 21OHD CAH had infrequent dyslipidemia, but had a higher prevalence of insulin resistance and central obesity, that were independent of BMI or corticosteroid dosage. © ABE&M todos os direitos reservados.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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