Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/108320
Type: Artigo de periódico
Title: Multifunctional Role Of Steroidogenic Factor 1 And Disorders Of Sex Development [papel Multifuncional Do Fator Esteroidogênico 1 E As Doenças Do Desenvolvimento Sexual]
Author: de Mello M.P.
de Souza Franca E.S.
Fabbri H.C.
Maciel-Guerra A.T.
Guerra-Junior G.
Abstract: Disorders of sex development (DSD) involve several conditions that result from abnormalities during gonadal determination and differentiation. Some of these disorders may manifest at birth by ambiguous genitalia; others are diagnosed only at puberty, by the delayed onset of secondary sexual characteristics. Sex determination and differentiation in humans are processes that involve the interaction of several genes such as WT1, NR5A1, NR0B1, SOX9, among others, in the testicular pathway, and WNT4, DAX1, FOXL2 and RSPO1, in the ovarian pathway. One of the major proteins in mammalian gonadal differentiation is the steroidogenic nuclear receptor factor 1 (SF1). This review will cover some of the most recent data on SF1 functional roles and fndings related to mutations in its coding gene, NR5A1. 2011;55(8):607-12. © ABE&M todos os direitos reservados.
Editor: 
Rights: aberto
Identifier DOI: 10.1590/S0004-27302011000800015
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84855437960&partnerID=40&md5=eb1cd22fb8545b1a0d44451095f0db83
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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