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Type: Artigo de periódico
Title: Facile Synthesis Of Symmetrical 3,3-diarylacrylates By A Heck-matsuda Reaction: An Expedient Route To Biologically Active Indanones
Author: Taylor J.G.
Ribeiro R.D.S.
Correia C.R.D.
Abstract: A simple and straightforward synthesis of symmetrical 3,3-diarylacrylates based on a Heck-Matsuda reaction of arenediazonium salts bearing electron-donating groups with methylacrylates is described. The reaction employs Pd(OAc) 2 as catalyst and goes to completion within 1 h affording the corresponding unsaturated diaryl esters in good to high yields. This method permitted the expeditious and efficient synthesis of the anticancer 3-arylindanone 5 in two operative steps in 43% overall yield. © 2011 Elsevier Ltd. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.tetlet.2011.05.039
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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