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|Type:||Artigo de periódico|
|Title:||Facile Synthesis Of Symmetrical 3,3-diarylacrylates By A Heck-matsuda Reaction: An Expedient Route To Biologically Active Indanones|
|Abstract:||A simple and straightforward synthesis of symmetrical 3,3-diarylacrylates based on a Heck-Matsuda reaction of arenediazonium salts bearing electron-donating groups with methylacrylates is described. The reaction employs Pd(OAc) 2 as catalyst and goes to completion within 1 h affording the corresponding unsaturated diaryl esters in good to high yields. This method permitted the expeditious and efficient synthesis of the anticancer 3-arylindanone 5 in two operative steps in 43% overall yield. © 2011 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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