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Type: Artigo de periódico
Title: Expeditious Synthesis Of 3,4-dihydroisocoumarins And Phthalides Using The Heck-matsuda Reaction
Author: Da Penha E.T.
Forni J.A.
Biajoli A.F.P.
Correia C.R.D.
Abstract: Several 3,4-dihydroisocoumarins and phthalides were synthesized by an effective Heck-Matsuda reaction involving an ortho carboxybenzenediazonium salt with a series of styrenes bearing electron donating and electron withdrawing groups, methylvinyl ketone, and methyl acrylate. The reaction was carried out in an open-flask with 1% mol of palladium acetate in aqueous ethanol at ∼80 °C, giving the correspondent 3-aryl-3,4-dihydroisocoumarins and phthalides with good overall yields. The electronic nature of the group attached to the olefin is a key feature for the regioselectivity of the cyclization step. © 2011 Elsevier Ltd. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.tetlet.2011.09.014
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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