Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/107949
Type: Artigo de periódico
Title: Prevention Of Muscle Fibrosis And Myonecrosis In Mdxmice By Suramin, A Tgf-β1 Blocker
Author: Taniguti A.P.T.
Pertille A.
Matsumura C.Y.
Neto H.S.
Marques M.J.
Abstract: Fibrosis is a pathological feature observed in patients with Duchenne muscular dystrophy (DMD) and in mdx mice, the experimental model of DMD. We evaluated the effect of suramin, a transforming growth factor-beta 1 (TGF-β1) blocker, on fibrosis in mdx mice. mdx mice (6 months old) received suramin for 7 weeks. Suramin-and saline-treated (control) mdx mice performed exercise on a treadmill to worsen disease progression. Immunoblotting showed an increase of TGF-β1 in mdx diaphragm, limb, and cardiac muscles. Suramin decreased creatine kinase in mdx mice and attenuated fibrosis in all muscles studied, except for cardiac muscle. Suramin protected limb muscles against damage and reduced the exerciseinduced loss of strength over time. These findings support a role for TGF-β1 in fibrinogenesis and myonecrosis during the later stages of disease in mdx mice. Suramin might be a useful therapeutic alternative for the treatment of dystrophinopathies. © 2010 Wiley Periodicals, Inc.
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Rights: fechado
Identifier DOI: 10.1002/mus.21869
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-78650501005&partnerID=40&md5=e0094e1d0c811705690d35329a65b969
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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