Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/107948
Type: Artigo de periódico
Title: O 2 Consumption Rates Along The Growth Curve: New Insights Into Trypanosoma Cruzi Mitochondrial Respiratory Chain
Author: Silva T.M.
Peloso E.F.
Vitor S.C.
Ribeiro L.H.G.
Gadelha F.R.
Abstract: Understanding the energy-transduction pathways employed by Trypanosoma cruzi, the etiological agent of Chagas disease, may lead to the identification of new targets for development of a more effective therapy. Herein, the contribution of different substrates for O 2 consumption rates along T. cruzi epimastigotes (Tulahuen 2 and Y strains) growth curve was evaluated. O 2 consumption rates were higher at the late stationary phase not due to an increase on succinate-dehydrogenase activity. Antimycin A and cyanide did not totally inhibit the mitochondrial respiratory chain (MRC). Malonate at 10 or 25 mM was not a potent inhibitor of complex II. Comparing complex II and III, the former appears to be the primary site of H 2O 2 release. An update on T. cruzi MRC is presented that together with our results bring important data towards the understanding of the parasite's MRC. The findings mainly at the stationary phase could be relevant for epimastigotes transformation into the metacyclic form, and in this sense deserves further attention. © Springer Science+Business Media, LLC 2011.
Editor: 
Rights: fechado
Identifier DOI: 10.1007/s10863-011-9369-0
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-80054771109&partnerID=40&md5=15cbd5c8261bc7f13f5a46996c6283aa
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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