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Type: Artigo de periódico
Title: Identification Of The Primary Outcomes That Result From Deficient Spiral Arterial Modification In Pregnant Mice
Author: Croy B.A.
Burke S.D.
Barrette V.F.
Zhang J.
Hatta K.
Smith G.N.
Bianco J.
Yamada A.T.
Adams M.A.
Abstract: Pre-eclampsia, an acute complication of human pregnancy, is associated with incomplete physiological modification of decidual spiral arteries. This is thought to promote oxidative stress from perfusion/reperfusion of the placenta and to restrict placental and fetal growth. Alymphoid (genotype Rag2 -/-/Il2rg-/-) mice, sufficient in dendritic and myeloid cell functions, lack spiral arterial modification with individual spiral arteries having ∼1.7× the vascular resistance and 0.66× the blood velocity of +/+ mice. Their placentae are not measurably hypoxic and neither placental growth nor fetal survival is impaired and gestational hypertension is not seen. Thus, lymphocytes rather than vascular adaptations appear to be the pivotal contributors to the clinical complications of pre-eclampsia. © 2010 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.preghy.2010.10.002
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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