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Type: Artigo de periódico
Title: Subclinical Regional Left Ventricular Dysfunction In Obese Patients With And Without Hypertension Or Hypertrophy
Author: Santos J.L.F.
Salemi V.M.C.
Picard M.H.
Mady C.
Coelho O.R.
Abstract: We investigated the impact of obesity on the abnormalities of systolic and diastolic regional left ventricular (LV) function in patients with or without hypertension or hypertrophy, and without heart failure. We studied 120 individuals divided into 6 groups of 20 patients (42 6 years, 60 females) using standard and pulsed-wave tissue Doppler imaging (TDI) echocardiography, and heterogeneity index (HI): nonobese (I: no hypertension, no hypertrophy, control group; II: hypertension, no hypertrophy; III: hypertension and hypertrophy) and obese (IV: no hypertension, no hypertrophy; V: hypertension, no hypertrophy; VI: hypertension and hypertrophy). The criterion for obesity was BMI 30kg/m -2, for hypertension was blood pressure 140/90mmHg, for hypertrophy in nonobese was LV mass/body surface area (BSA) 134g/m -2 (men) and 110mg/m -2 (women), and in obese was LV mass/height (2.7) 50 (men) and 40 (women). Obese groups had normal LV ejection fraction compared with nonobese groups, but decreased longitudinal and radial systolic myocardial peak velocities (S′), and early diastolic myocardial peak velocity (E′). Also, a great variability of E′ and late diastolic myocardial peak velocity (A′) from the longitudinal basal region was observed in obese groups (E′basal nonobese: 11 7 vs. obese 19 11, P 0.001, A′basal nonobese: 7 4 vs. obese 11 7, P 0.001). Our findings were more evident when comparing groups IV with V and VI, with the latter having concentric hypertrophy and obvious segmental systolic and diastolic dysfunctions. Subclinical myocardial alterations and increased variability of the velocities were observed in obese groups, especially with hypertension and hypertrophy, reflecting impaired regional LV relaxation, segmental atrial, and systolic dysfunctions. © 2011 The Obesity Society.
Rights: fechado
Identifier DOI: 10.1038/oby.2010.253
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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