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Type: Artigo de periódico
Title: Effects Of Cigarette Smoke On Osteogenesis And Bone Mechanical Resistance In Rats [efeitos Da Fumaça De Cigarro Sobre A Osteogênese E A Resistência Mecânica óssea Em Ratos]
Author: Bueno A.C.
Ribeiro K.G.
Cruz T.M.
Ivo T.P.F.
Nakagaki W.R.
Faria A.R.A.B.
Camilli J.A.
Garcia J.A.D.
Chavasco J.K.
Soares E.A.
Abstract: This paper reports a study of the effects of exposure to cigarette smoke on osteogenesis and the mechanical strength of bone in rats. Twelve male rats were separated into two groups (n=6): CT (control) and CI (cigarette). All the animals had free access to rat chow and water throughout the experiment. Group CI was exposed to the smoke of 6 cigarettes/day for 12 weeks. After 6 weeks of exposure to cigarette smoke, a defect was produced on the parietal bone and dense hydroxyapatite (DHA) ceramic bodies were implanted into cavities made surgically in the tibia of the animals, in each group. After surgery, the CT and CI groups returned to normal experimental conditions and, at the end of 12 weeks, they were euthanized, and their tibiae and parietal bones removed for histological processing, while the femurs were subjected to biomechanical tests in a MTS TestStar II three-point flexion module. Consumption of solid and liquid diet was satisfactory in both groups, all animals gaining weight throughout the experiment. CI animals showed a smaller volume of newly formed bone in the parietal defect (8.l9±0.2) and around the DHA implant in the tibia (33±0.5) than the rats in the CT group (14.4±0.5 and 39±1 respectively). The maximum force needed to break the femur was smaller in CI (119±3.2) than in CT (140±6.5). The results of this study led to the conclusion that exposure to cigarette smoke interfered with osteogenesis in the bone defect and around the DHA implant and reduced the maximum force required to completely break the femur, revealing that bone fragility can be caused by tobacco smoke.
Rights: aberto
Identifier DOI: 
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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