Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/107651
Type: Artigo de periódico
Title: ß-hydroxy-ß- Methylbutyrate (hm) Supplementation Stimulates Skeletal Muscle Hypertrophy In Rats Via The Mtor Pathway
Author: Pimentel G.D.
Rosa J.C.
Lira F.S.
Zanchi N.E.
Ropelle E.R.
Oyama L.M.
Oller Do Nascimento C.M.
De Mello M.T.
Tufik S.
Santos R.V.
Abstract: ß-Hydroxy-ß- methylbutyrate (HM) supplementation is used to treat cancer, sepsis and exercise-induced muscle damage. However, its effects on animal and human health and the consequences of this treatment in other tissues (e.g., fat and liver) have not been examined. The purpose of this study was to evaluate the effects of HM supplementation on skeletal muscle hypertrophy and the expression of proteins involved in insulin signalling. Rats were treated with HM (320 mg/kg body weight) or saline for one month. The skeletal muscle hypertrophy and insulin signalling were evaluated by western blotting, and hormonal concentrations were evaluated using ELISAs. HM supplementation induced muscle hypertrophy in the extensor digitorum longus (EDL) and soleus muscles and increased serum insulin levels, the expression of the mammalian target of rapamycin (mTOR) and phosphorylation of p70S6K in the EDL muscle. Expression of the insulin receptor was increased only in liver. Thus, our results suggest that HM supplementation can be used to increase muscle mass without adverse health effects. © 2011 Pimentel et al; licensee BioMed Central Ltd.
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Rights: aberto
Identifier DOI: 10.1186/1743-7075-8-11
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-79951851521&partnerID=40&md5=e723a688dff40d54faf0d3a8561721a9
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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