Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/107647
Type: Artigo de evento
Title: In Vitro Cytotoxicity Assays Of Solid Lipid Nanoparticles In Epithelial And Dermal Cells
Author: Ridolfi D.M.
Marcato P.D.
MacHado D.
Silva R.A.
Justo G.Z.
Duran N.
Abstract: In recent years, the interest in nanostructured systems to drug delivery has increased because they offer several advantages over conventional dosage forms. Solid Lipid Nanoparticles (SLN) have been highlighted among these systems because they have advantages such as high physical stability, protection against drug degradation and ease of scale-up and manufacturing, without using organic solvent. The aim of this work was to evaluate the potential of SLN, by in vitro cytotoxicity assays, for dermal drug delivery. SLN of three different lipids were prepared by hot high pressure homogenization and the cytotoxicity was assessed by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test in mouse 3T3 fibroblasts and human HaCaT keratinocytes. SLN showed no cytotoxic potential suggesting a great potential for dermal application.
Editor: 
Rights: aberto
Identifier DOI: 10.1088/1742-6596/304/1/012032
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-80052065752&partnerID=40&md5=2f0c0123f4ce8489778c41f487e18e39
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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