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|Title:||A Computer Tool For The Development Of Poly(lactic Acid) Synthesis Process From Renewable Feedstock For Biomanufacturing|
Maciel Filho R.
|Abstract:||The advances in medicine and engineering to treat loss or bad function of organs or tissues have motivated the development of biomaterials and techniques for biomanufacturing to improve life quality. Among these biomaterials (biopolymers), the poly(lactic acid) (PLA) has received significant attention. PLA is produced from lactic acid, a product that can be obtained by fermentation of sugars from renewable sources such as sugarcane and corn. PLA is thermoplastic and high strength material, and it is degraded in the body by simple hydrolysis of the ester at a rate that can be controlled. PLA and its copolymers are being used in the medical field in the form of implants or devices due to its excellent biocompatibility and biodegradability. PLA is a versatile polymer which can be produced with a wide spectrum of properties. It is extremely difficult to, experimentally, find out the optimal values of the many variables to achieve the required properties, since it is time consuming and expensive. Bearing this in mind, this work aims to simulate the PLA synthesis process from renewable feedstock in a commercial simulator (ASPEN PLUS®) identifying the polymer properties relation with operational conditions to obtain a final product with desired characteristics. © 2011 Elsevier B.V.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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