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Type: Artigo de periódico
Title: Chiral Allylsilane Additions To Chiral N-boc-α-amino Aldehydes
Author: Dias L.C.
Meira P.R.R.
Abstract: Addition of chiral allylsilane 4 to chiral N-Boc-α-amino aldehydes in the presence of SnCl4 in CH2Cl2 at -78 °C affords 1,2-syn homoallylic alcohols, potential intermediates for the synthesis of hydroxyethylene peptide isosteres. The diastereoselectivity depends on the aldehyde absolute configuration, with (R)-α-aminoaldehydes (matched case/anti-Felkin addition) exhibiting higher stereoselectivity than its enantiomer (mismatched case/Felkin addition).
Rights: aberto
Identifier DOI: 
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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