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|Type:||Artigo de periódico|
|Title:||Biological Activities Of Violacein, A New Antitumoral Indole Derivative, In An Inclusion Complex With β-cyclodextrin|
|Author:||De Azevedo M.B.M.|
|Abstract:||Violacein is a poorly water-soluble antitumoral and antibacterial drug. The solubility can be enhanced by complexation with β-cyclodextrin. The inclusion complex was prepared by the co-precipitation method in molar ratios of 1 : 1 and 1 : 2 of violacein/β-cyclodextrin, respectively. The acute toxicity (E. coli strain) of violacein did not change up to 400 μM, either in the presence or absence of cyclodextrin. Cytotoxicity (V-79 cell culture) through DNA and MTT assays was significantly decreased in the presence of the 1 : 2 molar ratio complex. Studies on erythrocyte lipid peroxidation by the thiobarbituric acid (TBA) method showed that violacein and violacein/β-CD (1 : 2) at 100 μM cause 50% and 80% inhibition, respectively. At 500 μM the violacein/β-CD complex inhibited lipid peroxidation completely; however, with free violacein only 65% inhibition was reached at that concentration.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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