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Type: Artigo de periódico
Title: Biological Activities Of Violacein, A New Antitumoral Indole Derivative, In An Inclusion Complex With β-cyclodextrin
Author: De Azevedo M.B.M.
Alderete J.
Rodriguez J.A.
Souza A.O.
Rettori D.
Torsoni M.A.
Faljoni-Alario A.
Haun M.
Duran N.
Abstract: Violacein is a poorly water-soluble antitumoral and antibacterial drug. The solubility can be enhanced by complexation with β-cyclodextrin. The inclusion complex was prepared by the co-precipitation method in molar ratios of 1 : 1 and 1 : 2 of violacein/β-cyclodextrin, respectively. The acute toxicity (E. coli strain) of violacein did not change up to 400 μM, either in the presence or absence of cyclodextrin. Cytotoxicity (V-79 cell culture) through DNA and MTT assays was significantly decreased in the presence of the 1 : 2 molar ratio complex. Studies on erythrocyte lipid peroxidation by the thiobarbituric acid (TBA) method showed that violacein and violacein/β-CD (1 : 2) at 100 μM cause 50% and 80% inhibition, respectively. At 500 μM the violacein/β-CD complex inhibited lipid peroxidation completely; however, with free violacein only 65% inhibition was reached at that concentration.
Rights: fechado
Identifier DOI: 
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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