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Type: Artigo de periódico
Title: Protective Immunity Induced By A Trypanosoma Cruzi Soluble Extract Antigen In Experimental Chagas' Disease. Role Of Interferon γ
Author: Garcia C.A.A.C.
Oliveira E.C.
Sakurada J.K.
Santos L.M.B.
Abstract: CBA/J mice can be protected against lethal infection with Trypanosoma cruzi by treatment using T. cruzi soluble extract antigen (TCSE). In vivo administration of TCSE (400 μg/mouse) into naive mice increased the cellular proliferative response to Con A and elevated the levels of IFN-γ. The production of IFN-γ was extremely important in controlling the replication of the parasite since the protective activity of TCSE was completely abrogated by in vivo treatment with an anti IFN-γ neutralizing antibody. These results suggest that depending on the level, cytokine production results in the control of replication of the parasite in experimental Chagas' disease.
Rights: fechado
Identifier DOI: 
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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