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|Type:||Artigo de periódico|
|Title:||Evaluation Of Minimal Residual Disease In Cml Patients Post Allogeneic Bone Marrow (bm) Or Peripheral Blood Stem Cells Transplantation (pbsc)|
|Abstract:||We evaluated in a prospective study 24 patients submitted to allogeneic transplantation of unmanipulated PBSC (n=8) or BM (n=l 6) for CML, using genotipically HLA identical sibling donors, between May 1998 and April 2000. Blood and BM samples for RT-PCR analysis for the detection of bcr-abl transcripts were collected during the follow-up post transplantation. Patients were evaluated monthly during the first year post transplantation, every 6 months during the next 2 years and once a year lately. A molecular relapse (MR) was defined by 2 consecutive positive RT-PCR assays in a 4-week interval. MR was detected in 14/24 (58.3%) patients in a median time of 37 months (19-130 months). According to the type of graft, MR was detected in 9/16 (56.3%) patients of BM group and 5/8 (62.5%) of PBSC (P=NS). Hematological relapse occurred in 2/14 patients with MR (14%). one in BM group and one in PBSC group (P=NS). The probability of MR in the first 180 days post transplantation was 60% (14/24 patients) ; Two out of thirteen (16%) évaluable patients became MR between 180 and 360 days. There was no MR in patients with follow-up > 360 days post transplantation (5 patients). Overall survival was 75% for PBSC group and 90% for BM (F=NS). There was 2 deaths: one caused by GVHD and one due to disease progression. Conclusions: MR rates were not affected by type of graft and were not associated with hematological relapse. However, patients with hematological relapse had persistent positive PCR. Further studies analyzing a higher number of patients are necessary to clarify the clinical implication of MR detection, to establish time points for early therapeutic interventions.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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