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|Type:||Artigo de periódico|
|Title:||Glutathiona S-transferase Mu L (gstm1) And Theta 1(gsttl) Genes: No Influence Of The Null Genotypes For The Risk Of Multiple Myeloma|
|Abstract:||Gluthationa S-transferases (GST) modulate the effects of exposure to various cytotoxic and genotoxic agents, including those associated with increased risk of the multiple myeloma (MM). Both the GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes have a null variant allele in which the entire gene is absent. In this study, we have tested whether null genotypes for the GSTM1 and GSTT1 genes altered the risk for MM. For this purpose, genomic DNA from 45 MM patients and one patient with plasma cell leukemia (23 male, 23 female; mean age +DP: 56 ±11 years) and 121 controls (95 males, 26 females; mean age ±DP: 54 ±3 years) was analysed using the polymerase chain reaction (multiplex-PCR). We observed similar frequencies of GSTM1 (37.0%) and GSTT1 (17.4%) null genotypes in MM patients and controls (47.1 % and 16.5 %, respectively; p = 0.31 and p = 0.92). We observed no differences in the frequencies of the combined null genotypes for both genes in patients and controls (4.3% vs 5.8%; p = 0.98). Our observation of a 0.66 (IC95%: 0.31-1.4) and 1.06 (IC95%: 0.30-2.82) risks associated with the GSTM1 and GSTT1 null genotypes, respectively, and a 0.74 (IC95%: 0.10-4.12) risk associated with the combined null genotype, suggests that the inherited absence of this carcinogen detoxification pathway could be unimportant for the aetiology of MM.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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