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Type: Artigo de periódico
Title: Changing Distribution Of Human Rotavirus Serotypes During Two Epidemic Outbreaks Of Gastroenteritis In Campinas, São Paulo, Brazil, 2003-2004: Detection Of G6 Strains
Author: Martini I.J.
Gennari G.M.
Martins S.S.
Gouvea V.S.
Gatti M.S.V.
Abstract: Background: Rotavirus serotypes G1-G4 and G9 are the most important agents of severe diarrhea in children worldwide. Objective: To characterize rotavirus serotypes/genotypes causing two large outbreaks of diarrhea in Campinas, São Paulo, during 2003-2004. Study: Rotavirus infection was investigated in 328 stool specimens collected from children and adults with diarrhea by PAGE and RT-PCR and further characterized by semi-nested PCR-typing assays. Results: G3P[8] (26.1%), G9P[8] (18.7%) and G1P[8] (17.9%) were the most frequently detected serotypes/genotypes. G1P[8] was predominant in 2003, but significantly decreased the following year when G3P[8] and G9P[8] prevailed. G5P[8] was identified in about 9% of the typed specimens from each year consistent with its endemic nature in Brazil for over two decades. The other globally common serotypes (G4P[8] and G2P[4]), uncommon G-P combinations, and multiple G serotypes were also found. Rarely found in humans, and not previously reported in Brazil, serotype G6 was identified in three specimens obtained from children in 2004. Conclusion: Multiple rotavirus serotypes were observed co-circulating in the city with serotype predominance changing between the two-year study. This study provides pre-vaccine baseline information on locally endemic strains that might help analysis of post-vaccine data. © 2008 Elsevier B.V. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.jcv.2008.06.015
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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